After scoring breakout roles in Superbad 11 years ago, Emma Stone and Jonah Hill will be reuniting for an upcoming show titled Maniac. The La La Land leading lady and 21 Jump Street actor/verified fashion icon feature in a new trailer for the Netflix series, which opens on them facing one another across a white table in a white-walled room.

The teaser trailer gets trippier, as a voiceover says: “Once you begin to appreciate the structure of the mind, there’s no reason to believe that anything about us can’t be changed. The mind can be solved.” Stone and Hill are promptly cast in a variety of hues, flicking between blue, green, red, and yellow. By the sounds of it, this trippy vibe will be reflective of Maniac itself, with Netflix executive Nancy Holland describing it as “a thought-provoking fever dream of a show”.

Helmed by True Detective’s Cary Fukunaga, Maniac is adapted from a Norwegian programme of the same name, which debuted in 2014, in which a psychiatric patient lives a life of idyllic delusion. Jonah Hill will play the possibly-schizophrenic son of wealthy New York industrialists, while Emma Stone will play an aimless woman fixated on her broken family relationships. Expect plenty of commentary on the pharmaceutical industry mixed in with its dark comedy.

Alongside Hill and Stone, Justin Theroux will play Dr. James K. Mantleray, a doctor convinced he can fixed anyone with a pill he’s invented.

The 10-episode ‘limited series’ is slated to have its premiere on Netflix, September 21.